• We also demonstrate that PACAP treatment

  2024-06-17

  

  We also demonstrate that PACAP treatment dose-dependently disrupts performance in the 5CSRTT, suggestive of attentional deficits, another core feature of mood and anxiety disorders. Treatment with PACAP (.5–1.0 µg) decreased the percentage of correct responses, increased the percentage of trials in

• br Discussion Mycobacterium tuberculosis infection is a main

  2024-06-17

  

  Discussion Mycobacterium tuberculosis infection is a main threat to mankind, with one third of the world population being infected. [9] Over nine million new cases of tuberculosis and two million deaths from this disease occur yearly worldwide. [10] The rising incidence of tuberculosis over the l

• We also investigated the transmittance of

  2024-06-17

  

  We also investigated the transmittance of actin polymerized with and without ABP. The presence of actin in the solution results in an increment in turbidity as other proteins provided glycerophosphate mg features [21], [32]. While G-actin showed a transmittance peak positioned at 241 nm, F-actin ex

• br Conflict of interest statement br Benign prostatic hyperp

  2024-06-17

  

  Conflict of interest statement Benign prostatic hyperplasia (BPH) is a highly complex process characterized by an increased number of epithelial and stromal blt2 sale in the transition zone. , , Autopsy studies by McNeal detail the evolution of histological changes within these 2 cellular com

• br COX and LOX in post mortem AD brain

  2024-06-17

  

  COX and 5-LOX in post-mortem AD brain Minghetti (2004) reviewed the findings on COX-2 mRNA levels in AD brains, pointing out that the available evidence demonstrated either decreased or increased levels, possibly because of the short half-life of COX-2 transcripts or individual variability. Histo

• br Acknowledgements MC and PD were funded by the

  2024-06-17

  

  Acknowledgements MC and PD were funded by the Michael J Fox Foundation (Grant ID 9969). We would like to thank Pierluigi Saba, Francesco Traccis and Barbara Tuveri for their technical assistance. Introduction In the prostate, androgens play a crucial role in normal, BPH and cancerous growth b

• A variety of quinazoline or fused pyrimidine substituted dia

  2024-06-17

  

  A variety of quinazoline or fused pyrimidine-substituted diaminotriazoles showed sub-100nM inhibition of Axl (). Diaminotriazoles similarly substituted with quinolines, isoquinolines and benzothiazoles also showed potent Axl activity (data not shown), but generally exhibited potent cytotoxicity and

• The acidification of endocytic compartments is closely

  2024-06-17

  

  The acidification of endocytic compartments is closely related to endocytic activity, although the mechanism linking acidification and membrane dynamics is largely unknown. In a recent RNA interference (RNAi)-based screen, V-ATPase depletion blocked the formation of clathrin-coated vesicles, an effe

• In our studies of leucine and BCH in pancreatic

  2024-06-17

  

  In our studies of leucine and BCH in pancreatic islets and clonal insulin cell lines, we noticed that leucine was a slightly stronger stimulant of insulin release. Previous studies showed that leucine can be metabolized to CO2[11], [12], [13], [14] and can increase acetoacetate in pancreatic islets

• How does the ATM to ATR switch occur

  2024-06-17

  

  How does the ATM-to-ATR switch occur at DSBs? The progressive attenuation of ATM activation could be attributed to the loss of DNA structures that activate ATM, or to the generation of DNA structures that interfere with ATM activation. Our finding that SSOs do not directly affect the binding of puri

• In the nineties we knew that

  2024-06-17

  

  In the nineties we knew that (-)baclofen was the stereo-selective ligand for the GABAB receptor which had been recognised by Norman Bowery as a receptor for GABA, which was different from the GABAA receptor (Hill and Bowery, 1981). GABAB receptor antagonists were also synthesised and made available

• br Roles of apelin and APJ in

  2024-06-17

  

  Roles of apelin and APJ in cardiovascular diseases Therapeutic potential of apelin/APJ in cardiovascular diseases Since the apelin/APJ system plays a key role in the occurrence and development of cardiovascular diseases, it seems logical to presume that targeting this axis should be feasible a

• Therefore VEGF and its receptors are

  2024-06-17

  

  Therefore, VEGF and its receptors are expressed in different organs, including the kidneys, the liver and the salidroside [55]. In the human placenta, VEGF is mainly synthesized by cytotrophoblast and Hofbauer cells early in the first trimester, whereas Flk-1 and Flt-1 receptors are expressed throug

• aa dutp Although mature fibrils formed from A aggregates hav

  2024-06-17

  

  Although mature fibrils formed from Aβ aa dutp have long been thought to be the main neurodegenerative agents in AD, recent evidence suggests that soluble multimers of these pathogenic proteins, referred to here as “oligomers,” may initiate the synaptic and neuronal dysfunction associated with AD a

• br Acknowledgements This work was supported by Programme Gra

  2024-06-17

  

  Acknowledgements This work was supported by Programme Grants from the MRC and the Wellcome Trust (SGC-C and MF). CB was in receipt of a Marie Curie Intra-European Fellowship during part of this work. We thank past and present members of our group for numerous valuable discussions throughout these

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