• br Materials and methods All animal experiments were perform

  2024-11-27

  

  Materials and methods All animal experiments were performed using the recommendations of the Guide for the Care and Use of Laboratory Animals (National Research Council, 2011) and approved by the University of Colorado—Denver Institutional Animal Care and Use Committee. Adult male Sprague—Dawley

• A rational approach for the design of new steroid

  2024-11-27

  

  A rational approach for the design of new steroid compounds as possible competitive inhibitors of CYP17 include chemical modification at C17 of the enzyme's natural substrates, pregnenolone (1) and progesterone (2), introducing groups with moderate to strong dipole properties at C20, such as oxime a

• Herein we disclose novel dihydropyrano c pyrazoles

  2024-11-27

  

  Herein, we disclose novel 2,4-dihydropyrano[2,3-c]pyrazoles that inhibit human ATX (hATX). Our results demonstrate and further support previous findings showing that a desired biological action can be achieved without targeting the catalytic site of the enzyme. Moreover, this study validated hen egg

• It was reported that overexpression of the rat ACL gene

  2024-11-27

  

  It was reported that overexpression of the rat ACL gene in tobacco increased the total ACL activity by 4 fold, which increased the production of fatty acids by 16% [8]. Recently, a 1.7-fold increase of fatty acids and 1.9-fold increase of triacylglycerol (TAG) was observed in Aspergillus oryzae with

• Arginase deficiency is a rare urea cycle disorder

  2024-11-27

  

  Arginase deficiency is a rare urea cycle disorder with hyperargininemia and profound neurological impairment as hallmark features. Arginase-1-deficient mouse models have been created, and they exhibit a profound lethal phenotype approximately 2 weeks after birth in the global knockout (KO) mice or a

• Autophagy and apoptosis have a very complex

  2024-11-27

  

  Autophagy and apoptosis have a very complex relationship, and the precise mechanism remains to be determined. At present, a large amount of research has confirmed that autophagy can protect the cell from apoptosis in special conditions such as nutrient deficiency or growth factors deprivation; the e

• br Concluding remarks The past decade has seen

  2024-11-26

  

  Concluding remarks The past decade has seen rapid advances in our understanding of the metabolic reprogramming that occurs during tumorigenesis. Strategies to target specific nodes of cancer cell amino Myriocin australia metabolism have progressed from preclinical studies to clinical trials, and

• We have previously reported that interfering

  2024-11-26

  

  We have previously reported that interfering with Splitomicin mg assembly dynamics by knocking down cofilin-1 in hMSCs increased polymerized actin that promoted osteoblast cell differentiation through a mechanism of enhancing focal adhesion kinase (FAK), p38 and c-Jun N-terminal kinase (JNK) signal

• br ACK inhibitors Since ACK activation is

  2024-11-26

  

  ACK1 inhibitors Since ACK1 activation is correlated with poor prognosis in various cancers, strong efforts are being directed by multiple groups towards developing highly potent and specific small molecule inhibitors targeting the ACK1 kinase. At least eight small molecule kinase inhibitors have

• Regarding androgens it is known that

  2024-11-26

  

  Regarding androgens, it is known that they are also essential for reproductive success (Walters et al., 2010). At the molecular level, their effects are produced mainly by dihydrotestosterone (DHT), arising from the conversion of testosterone by the enzyme 3-oxo-5-alpha-steroid-4-dehydrogenase (enco

• br Autophagy and antiviral innate

  2024-11-26

  

  Autophagy and antiviral innate immunity signaling Viral manipulation of autophagy interfering with IFN-I synthesis We have seen that autophagy factors can down-regulate the production of IFN-I induced by RLR engagement during viral infection. In fibroblasts and epithelial cells, there exists c

• Inactivation of the proton pump

  2024-11-26

  

  Inactivation of the proton pump comes with luminal alkalinization of the targeted vesicles such as lysosomes (Fig. 2b). Lysosome pH can also be raised stoichiometrically by addition of a membrane-permeable weak SB 258719 hydrochloride such as methylamine or chloroquine which accumulates in its prot

• br Drugs with documented pro apoptotic effects on platelets

  2024-11-25

  

  Drugs with documented pro-apoptotic effects on platelets More than 200 drugs are reported to cause thrombocytopenia [5,42]. The concept of platelet apoptosis is relatively new and was only recently evaluated in the context of drug-induced thrombocytopenia [43]. Table 2 lists the drugs presently k

• The elevated levels of intracellular antioxidant such as

  2024-11-25

  

  The elevated levels of intracellular antioxidant such as reduced glutathione (GSH) are normally oberserved is various tumor leukotriene receptor agonist which confers the chemoresistant to chemotherapy [59]. Therefore, the induction of oxidative stress via elevation of intracellular ROS and dimuniti

• br Introduction The apelin receptor angiotensin

  2024-11-25

  

  Introduction The apelin receptor (angiotensin receptor-like 1, APJ) is a seven transmembrane receptor (7TMR) that belongs to the class A peptidergic G protein-coupled receptors (GPCR) superfamily [1]. The endogenous ligands of APJ are the different isoforms of apelin (namely apelin-13, −17, and −

14208 records 14/948 page Previous Next First page 上5页 1112131415 下5页 Last page