• The apocrine sweat glands of

  2023-09-19

  

  The apocrine sweat glands of the human axilla produce odor substances with pheromone functions whose nature corresponds to volatile steroids (Cowley and Brooksbank, 1991, Grosser et al., 2000, Sobel et al., 1999, Weller, 1998). These functions only begin with puberty, indicating that sex hormones st

• The current results also demonstrated tendencies toward decr

  2023-09-19

  

  The current results also demonstrated tendencies toward decreased serum Aβ40 levels and increased Aβ42 levels during the 1-year follow-up. These tendencies are consistent with the results of a previous study that evaluated Aβs in the CSF of patients with late-life depression (Pomara et al., 2016). T

• on average br Materials and methods br Results Table present

  2023-09-19

  

  Materials and methods Results Table 1 presents the metabolic phenotype of obese minipigs. After 60 d of HFHS feeding, minipigs not only showed an increased body weight (+45%), but also a perturbed on average homeostasis, with higher insulin levels (about +2-fold), HOMA-IR (+5.5-fold), and HOM

• To confirm a role of OCT in corticosterone induced

  2023-09-19

  

  To confirm a role of OCT3 in corticosterone-induced potentiation of cocaine-primed reinstatement, we examined the interaction of corticosterone and cocaine in the reinstatement of cocaine conditioned place preference (CPP) in wild type mice, and transgenic OCT3-deficient mice. These mice express a t

• Based on the observation that antipsychotic

  2023-09-19

  

  Based on the observation that antipsychotic drugs increase 5-HT1A–D2 heteromerization level (Łukasiewicz et al., 2016), we set out to compare the effect of paroxetine to that of risperidone. Paroxetine, a potent SSRI, is very effective in the treatment of depression and anxiety disorders, e.g., gene

• In conclusion the results of

  2023-09-19

  

  In conclusion, the results of this investigation suggest that the involvement of PGE2 in the pathogenesis of pulpal inflammation and repair may be related to its induction of cAMP production. PGE2-induced cAMP production in dental pulp cells is mediated by binding to the EP2 receptor, activation of

• br Materials and methods br

  2023-09-19

  

  Materials and methods Results Discussion In this study, we observed that PACAP2 immunoreactivity is mainly distributed in the telencephalon, hippocampus, and cerebellum of the zebrafish brain. This distribution pattern is similar to that reported in a previous study in which PACAP immunorea

• br Experimental procedures Adk tg Adktm

  2023-09-19

  

  Experimental procedures Adk-tg (Adktm1−/−:tg(UbiAdk) mice were created by breeding a loxP-flanked Adk transgene under the control of a human ubiquitin promoter into ADK knockout mice (Fedele et al., 2005,). Fb-Adk-def (Adktm1−/−:tg(UbiAdk):Emx1-Cre-tg3) mice were generated by pairing Emx1-Cre-tg3

• By promoting bundling and processive elongation of

  2023-09-19

  

  By promoting bundling and processive elongation of aminopeptidase inhibitor filaments and inhibiting association of capping protein with filament barbed ends, Ena/VASP family proteins contribute to the dynamics of lamellipodia and filopodia [41] and maintenance of focal adhesions and tight junctions

• The indirect effect of corporate taxation as given by

  2023-09-19

  

  The indirect effect of corporate taxation, as given by the second term in Eq. (18), consists of two elements; (i) a standard tetracaine hydrochloride synthesis effect (τ/n2), and (ii) a capital cost effect (rG(1−αt)/(1−t)). With a CRS technology, the cost effect vanishes, whereas with an IRS (a DRS

• NLX a k a F or befiradol exhibits nanomolar

  2023-09-19

  

  NLX-112 (a.k.a. F13640 or befiradol), exhibits nanomolar affinity at 5-HT1A receptors, and, in histone demethylase to the 5-HT1A receptor agonists listed above, it presents exceptional selectivity and high efficacy at these receptors (Colpaert et al., 2002, Newman-Tancredi et al., 2017). Additionall

• br Autophagy and cell death

  2023-09-19

  

  Autophagy and cell death pathways in ischemic stroke Although very important for the effects on post-ischemic ap1 injury, autophagy is not the only mechanism of action involved in cell death. Necrosis and apoptosis are two other distinct forms of cell death with great difference in morphology an

• V ATPase is a complex enzyme that is composed of

  2023-09-19

  

  V-ATPase is a complex enzyme that is composed of several subunits, which are assembled into two domains: trans-membrane (V0) and cytosolic (V1) domains [3,5]. Epididymal epithelial A-443654 of rats has been reported to contain V-ATPase which is distributed at the apical pole of the narrow and clear

• br Conclusion This is the first report

  2023-09-19

  

  Conclusion This is the first report to show that treatment of lung cancer cell lines, A549 and H1299, with ovatodiolid stimulates intracellular reactive oxygen species generation and induces DNA damage. Subsequently activates ATM/ATR and CHK1/2 signaling pathway, inhibits CDC25C and p21WAF1/CIP1,

• br Extracellular domain architecture The extracellular regio

  2023-09-19

  

  Extracellular domain architecture The extracellular region of GABAB receptor exists in a heterodimeric configuration regardless of interactions within the rest of the protein (Geng et al., 2012, Liu et al., 2004, Nomura et al., 2008). The extracellular domains of the GABAB1 and GABAB2 subunits ar

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