• br Materials and methods br

  2021-01-21

  

  Materials and methods Results Discussion Cisplatin, as one member of a class of platinum-containing anti-cancer drugs, which displays a great deal of clinical activity on a wide variety of solid tumors. In addition, cisplatin often used in combination with other chemotherapy drugs to treat

• br Materials and methods br

  2021-01-21

  

  Materials and methods Results Discussion In particular, we showed that pancreatic neuroendocrine tumor Milrinone synthesis recognize cAMP as a stimulatory signal for cell proliferation. Conversely, cAMP was found to have an inhibitory effect on cell proliferation in bronchial carcinoids ce

• br STAR Methods br Acknowledgments We

  2021-01-21

  

  STAR★Methods Acknowledgments We would like to thank Dr. Tsung-Ping and Dr. Shang-Yi Tsai, National Institute on Drug Abuse, NIH for sharing protocols on pulse chase experiments and analysis. We would like to thank Dr. William G. Telford for his valuable input on Amnis flow cytometry experiment

• C-type natriuretic peptide (1-22) (human, rat, swine) A key

  2021-01-21

  

  A key inciting event in atherosclerosis is the deposition of circulating low-density lipoprotein (LDL) in the subendothelial space of major arteries. In the subendothelium, native LDL is no longer protected by circulating antioxidants and is oxidatively modified to oxidized LDL (OxLDL) [5]. OxLDL is

• br DDR receptor and MMP expression

  2021-01-20

  

  DDR2 receptor and MMP-13 expression Type II collagen protein in articular cartilage is highly stable structure as its half-life is 117 years [43]. The chondrocytes have limited ability to synthesis type II collagen protein in the matrix of mature articular cartilage once the collagen gets disrupt

• CDK S phosphorylation status influences the differential cel

  2021-01-20

  

  CDK5-S47 phosphorylation status influences the differential cellular proliferation versus migration response: Previous work from our laboratory has shown CDK5 to be a critical determinant of the cellular proliferation-migration dichotomy whereby CDK5 activation downstream of stimulated epidermal gro

• The early serologic response of infants to infection with

  2021-01-20

  

  The early serologic response of infants to infection with HIV-1 is obscured by the presence of transplacentally acquired maternal HIV antibody. However, the HIV DHT receptor produced in vitro by peripheral blood from infants has been studied (Pollack et al., 1993) and it has been shown that neonata

• Park et al expanded their own

  2021-01-20

  

  Park et al. [34] expanded their own model as hydrogen- bonding lattice fluid EOS (NLF-HB) [35] for calculating the activity coefficients of aqueous amino all the way solution. Further, Pazuki et al. [36] extended the perturbed hard chain theory which has been proposed by Beret and Prausnitz [37] fo

• While lowering the TID exposure of electronics

  2021-01-20

  

  While lowering the TID exposure of electronics is fairly straightforward, there are other xanthine oxidase induced effects that are not as easily mitigated, especially with COTS components. Single Event Effects (SEE) occur when a high-energy particle strikes the active area of an integrated circuit,

• Unlike many forms of SNHL cCMV

  2021-01-20

  

  Unlike many forms of SNHL, cCMV may be treatable. The antiviral drug valganciclovir (VGCV) has been proposed to improve hearing, speech, and language outcomes associated with this infection [6]. A recent publication from the CASG (Collaborative Antiviral Study Group) reported that a six-month course

• Namely the NOESY cross peaks between H

  2021-01-20

  

  Namely, the NOESY cross-peaks between H-7″ methylene protons ( 4.01 and 4.16) with H-6′ ( 6.76) revealed that H-2 and OH-3 are -orientated, which indicated that the relative configuration of the C2 and C3 substituents as . For the -isomers, the thermodynamically more stable conformation is when H-2

• Additionally both in vitro and in vivo studies showed that

  2021-01-20

  

  Additionally, both in vitro and in vivo studies showed that a Ca2+ influx is closely related to apoptosis (Rizzuto et al., 2003). Calmodulin (CaM) is a multifunctional intermediate calcium-binding messenger protein expressed in all eukaryotic cells, which senses intracellular calcium levels by bindi

• br Oxidoreductase like MEM for prodrug activation

  2021-01-20

  

  Oxidoreductase-like MEM for prodrug activation Future outlook Although MEM-mediated prodrug activation has been performed by different MEMs and prodrugs, and their effectiveness have been proved in vivo, only a few types of MEMs or prodrugs have been explored in prodrug activation until now [2

• At the therapeutic level the logical approach to address the

  2021-01-20

  

  At the therapeutic level, the logical approach to address the cooperation between FGFR4 and EGFR was the combined inhibition of both receptors. To explore the potential efficacy and specificity of this approach, we tested the effect of FGFR and EGFR inhibitors in monotherapy or in combination in syn

• br Enzymes involved in microbial steroid degradation are gen

  2021-01-19

  

  Enzymes involved in microbial steroid degradation are generally not expressed constitutively, but they are upregulated depending on which steroid substrates are present [17,81]. Thus, a cell-free extract prepared from testosterone-adapted C. testosteroni ATCC 11996 cells displayed a 1(2)-dehydroge

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