• br Acknowledgements br Introduction Bacteriophages are consi

  2020-08-07

  

  Acknowledgements Introduction Bacteriophages are considered as the most abundant organisms on earth that exist almost in all environments particularly where bacteria flourish, such as in wastewater and sewage [12]. One of these bacteriophages that is extensively studied is the T4 bacteriophage

• LY3009120 br Conclusions In this paper we have succeeded in

  2020-08-07

  

  Conclusions In this paper we have succeeded in what we fail in our previous report [5]. In this case we have been able to get an excellent correlation between the electronic densities obtained from a QTAIM study with the experimental data. It is important to note that through this study is possi

• DGK silence induced by promoter hypermethylation

  2020-08-06

  

  DGKγ silence induced by promoter hypermethylation has been reported in colorectal cancer [15]. To address the underlying mechanism contributed to the aberrant DGKγ down-regulation seen in HCC tumor tissues, we first investigated the methylation status of DGKγ gene promoter in HCC tissues and cell li

• Next we tried to specifically inhibit DDR function

  2020-08-06

  

  Next, we tried to specifically inhibit DDR2 function in endochondral proliferation and ossification in vivo. We used competitive inhibition with KD-Ddr2 overexpression specifically in cartilage cells, because it is generally difficult to regulate genes by miRNA in vivo. We constructed a transgenic v

• A second mode of collagen

  2020-08-06

  

  A second mode of collagen regulation reported earlier by our laboratory shows that the ECD of DDR1 or DDR2 when expressed as a soluble protein can modulate fibrillogenesis of collagen type 1 in-vitro.18, 19 In particular, we found that DDR2 ECD delays collagen fibrillogenesis and the collagen fibers

• Our recent studies demonstrated that a lesion

  2020-08-06

  

  Our recent studies demonstrated that a lesion or activation of the tuberoinfundibular or the mesolimbic pathway of the BMS-345541 dopaminergic system affects liver CYP activity and protein level (CYP1A, CYP2B, CYP2C11 and CYP3A), as well as blood plasma concentration of the respective pituitary hor

• CDK lacks DNA binding domains and nuclear localization seque

  2020-08-06

  

  CDK6 lacks DNA-binding domains and nuclear localization sequences, and therefore will probably be transported to the nucleus by a ‘piggy-back’ mechanism and needs to contact its specific sites indirectly through DNA-binding proteins. Besides NF-κB p65, a further candidate transcription factor is PAX

• Acute renal failure in cats can arise

  2020-08-06

  

  Acute renal failure in cats can arise from numerous causes [34], [35], [36], [37], [38], [39], [40] and has a very poor prognosis [36], [41]. Many cats who survive to discharge are azotaemic and, as a result, are likely to have high morbidity and greatly-reduced lifespan, while a second “wave” of ap

• Although expression of Chk inhibits cell proliferation of

  2020-08-06

  

  Although expression of Chk inhibits cell proliferation of a human breast carcinoma cell line in a kinase activity-dependent manner [17], [18], inactivation of Src-family kinases by Chk is also reported in a manner that is independent of the kinase activity of Chk, where the direct binding of Chk to

• Besides being the only enzyme E is

  2020-08-05

  

  Besides being the only enzyme, E1 is also the largest and arguably most complex protein encoded by papillomaviruses. As the replicative helicase, E1 plays a central role in the viral life cycle. To do so, E1 engages in multiple protein–protein and protein–nucleic (R,S)-Anatabine interactions to cre

• Caspase-1, human recombinant proteinase br Materials and met

  2020-08-05

  

  Materials and methods Results Discussion CuE showed to possess a number of biological activities, but its hepatotoxicity remains unclear. Moreover, the widespread use of CuE-containing medicines has led to increasing concerns on potential drug-drug interactions through metabolic enzyme pat

• Introduction The first reference to a

  2020-08-05

  

  Introduction The first reference to a possible involvement of orexins in the effects of drugs of abuse appeared in 2003 and showed that orexigenic peptide neurons respond to the chronic administration of morphine followed by abrupt withdrawal symptoms caused by opioid receptor antagonists (Georgesc

• br Introduction Currently the great offer

  2020-08-05

  

  Introduction Currently, the great offer of unhealthy diets, rich in saturated fat, increases the prevalence of metabolic disorders [1], [2], [3]. The metabolic syndrome is already established in the worldwide population and is not limited to overweight or obese persons. This disorder refers to a

• br Introduction A major limiting

  2020-08-05

  

  Introduction A major limiting factor in cancer chemotherapy is the toxicity of cytotoxic drugs to normal tissues. Attempts to circumvent this problem have led to the tumour targeting approach, and trans-isomer to tumour-associated proteins have been used in the development of a number of targeted

• Despite the evidence accumulated on the involvement

  2020-08-05

  

  Despite the evidence accumulated on the involvement of ETs and their receptors in many pain states, their potential contribution to nociception following SCI has not yet been investigated. Hence, the present study was designed to assess the roles exerted by ETAR and ETBR in neuropathic pain after SC

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