• Both anxiogenic and antinociceptive effects produced by CRF

  2020-07-29

  

  Both anxiogenic and antinociceptive effects produced by CRF seem to be selective for the CRF1 receptor, since intra-dPAG microinjection of ASV 30, a CRF2 receptor antagonist, altered neither the anxiety nor the antinociception response. Intra-dPAG ASV 30 was also unable to prevent the anxiogenic (ob

• From the same perspective previous studies by

  2020-07-29

  

  From the same perspective, previous studies by Sajdyk and colleagues (Sajdyk et al., 1999) and Spiga and colleagues (Spiga et al., 2006) have shown that the administration of CRF or urocortin 1 (a selective agonist for CRF1 and CRF2 receptors but with a higher affinity for the CRF1 receptor) into th

• Physiological changes induced by CRF are mediated through CR

  2020-07-29

  

  Physiological changes induced by CRF are mediated through CRF1 and CRF2 receptors (Chang et al., 1993, Lovenberg et al., 1995). Previous findings with CRF1 receptor antagonists showed that activation of CRF1 receptor is involved in maternal separation-induced ultrasonic vocalizations (Kehne et al.,

• In the present study we aimed to investigate the effect

  2020-07-29

  

  In the present study, we aimed to investigate the effect of the non-specific DNMT inhibitor RG108 on pattern separation performance and therefore provide first evidence regarding the influence of an epigenetic mechanism on pattern separation memory. Next, in order to get more insight into the effect

• DNA damage is associated with the initiation

  2020-07-29

  

  DNA damage is associated with the initiation step of carcinogenesis. Our results reveal that arsenite and BaP co-exposure decreases the number of γ-H2AX foci. γ-H2AX is involved in the recruitment and accumulation of DNA repair proteins to sites of damage (Fernandez-Capetillo et al., 2003, Fillingha

• Esomeprazole Sodium Currently much effort has been made to d

  2020-07-28

  

  Currently, much effort has been made to design and synthesize ThDP analogs (such as ThTDP, ThTTDP, and triazole-ThDP in Fig. 2)8, 9, 10, 11, 12 as PDHc E1 inhibitors. These ThDP analog inhibitors, such as ThTDP and ThTTDP, can block the ThDP binding site, and exhibit significantly stronger binding a

• br Competing interests br Acknowledgements This work

  2020-07-28

  

  Competing interests Acknowledgements This work was supported by a Grant-in-Aid for Scientific Research (KAKENHI) from the Ministry of Education, Culture, Sports, Science, and Technology (MEXT) (26304036), Japan. Introduction Cancer is a disease of dysregulated cell growth and metabolism-re

• gpr119 agonist br Conflict of interest statement

  2020-07-28

  

  Conflict of interest statement Introduction Colorectal cancer is the most serious long-term complication in patients with chronic inflammatory bowel disease. Patients with long-standing ulcerative colitis (UC) are at increased risk of developing colorectal carcinoma (CRC) compared to the gener

• br Conclusion br Conflict of interest br Prostaglandin D PGD

  2020-07-28

  

  Conclusion Conflict of interest Prostaglandin D2 (PGD) is the major prostanoid released by mast cells during allergic attacks., In human patients, allergen challenge leads to a rapid increase in the production of PGD in the airway of asthmatics, in the nasal mucosa of allergic rhinitics and

• In this study we discovered that

  2020-07-28

  

  In this study, we discovered that CRM1 was increased in the intestinal tissues of patients with active CD in whom ser10-phosphorylated p27 was also elevated, whereas the expression of p27kip1 was decreased. In vitro experiments revealed that increased expression of CRM1 was consistent with elevated

• Many studies have used paradigms

  2020-07-28

  

  Many studies have used paradigms based on animal models to understand human emotional behavior because it appears to be correlated with fear- and anxiety-related defensive patterns in non-human mammals (Blanchard et al., 2001). In this case, defensive reactions are used to study the neural substrate

• [Ala92]-p16 (84-103) It has been emphasized that CRF

  2020-07-28

  

  It has been emphasized that CRF can activate Gs-protein-coupled CRF1 or CRF2 receptors triggering the cAMP-PKA cascade pathway (Chang et al., 1993, Chen et al., 1993, Lovenberg et al., 1995, Perrin et al., 1995, Vita et al., 1993). Moreover, both receptor subtypes have been found strongly expressed

• br Multi hierarchical structure of collagen Protein

  2020-07-28

  

  Multi-hierarchical structure of collagen Protein structure is the foundation of protein functions and properties. It is generally accepted that the protein has biological function only when it has tertiary structure or above. Among the identified 28 types of collagen, most is known about type I c

• The innovation of new compounds and new mechanisms

  2020-07-28

  

  The innovation of new compounds and new mechanisms for studying the role of highly active antiviral compounds has become the focus of research attention (Gao et al., 2012; Li et al., 2007; Long et al., 2015; Chen et al., 2016; Zhang et al., 2016; Xie et al., 2018; Wu et al., 2017; Zhang et al., 2017

• Another significant finding in our study was the demonstrati

  2020-07-28

  

  Another significant finding in our study was the demonstration that the axon-protective action associated with CK2 inhibition correlated with preservation of mitochondrial structure and function in Biotin-azide (Fig. 11). Because of the consistent protection conferred by CK2 inhibition during OGD,

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