• EC barrier dysfunction triggered by inflammatory mediators i

  2019-11-14

  

  EC barrier dysfunction triggered by inflammatory mediators involves more than one mechanism, explaining the partial attenuation of EC barrier compromise obtained with PKA and Epac activators. PKA-dependent phosphorylation of vasodilator-stimulated phosphoprotein (VASP) has been shown to make a posit

• br Materials and methods br Results br

  2019-11-14

  

  Materials and methods Results Discussion The investigation of oxysterols is highly complex and challenging, arising not only from the large number of molecules in this family, but also due to their low abundance in biological systems compared to cholesterol and their susceptibility for auto

• In the belief that DNA based

  2019-11-13

  

  In the belief that DNA-based nanosensors and DNA microarrays should be easier to operate, faster, more accurate and more economically viable than PCR-based techniques, an electrochemical DNA biosensor was designed for detection of G. boninense[9], [10]. This was developed based on a gold electrode m

• In Senegal malaria remains a formidable public health issue

  2019-11-13

  

  In Senegal, malaria remains a formidable public health issue, causing significant morbidity and mortality in infants and pregnant women (WHO Malaria Report, 2012). In the absence of an effective vaccine, the National Malaria Control Program has followed WHO recommendations for IPTp-SP since 2003. Th

• During the Lapita period in

  2019-11-13

  

  During the Lapita period in Tonga, the Talasiu site would have been an attractive location for human settlement as it overlooked an embayment holding large numbers of sessile and gregarious shellfish close to a fresh water solution channel, with gardening soils immediately inland. However, sea level

• The contradictory effects exerted by metals were reviewed by

  2019-11-13

  

  The contradictory effects exerted by metals were reviewed by Nunes (2011) that stated that the concentration and the species of metal can cause specific effects in ChE activity. Being environmentally exposed, the organism can accumulate metals in tissues, increasing their concentrations. Some author

• NSC 207895 Water inorganic salts sugars lipids nucleic

  2019-11-13

  

  Water, inorganic salts, sugars, lipids, nucleic acids and proteins are the main basic materials forming the organism. Life activities can be controlled or regulated by a series of complicated and chain-reactive protein–protein interactions. Protein–protein interaction is considered as the bases and

• In a study performed simultaneously by another group EWS

  2019-11-13

  

  In a study performed simultaneously by another group, EWS-FLI-1 introduction into unsorted murine bone marrow-derived Verdinexor receptor resulted in tumors with various phenotypes including one that is consistent with that of Ewing sarcoma [68]. The tumors expressed markers associated with Ewing sa

• br Conflicts of interest br Financial

  2019-11-13

  

  Conflicts of interest Financial support NZ is an Established Investigator of the Dutch Heart Foundation (2013T111) and is supported by an ERC Consolidator grant (617376) from the European Research Council and by a Vici grant from the Netherlands Organization for Scientific Research (NWO; 91818

• TASIN-1 Eggs have been recognized as an important contributo

  2019-11-13

  

  Eggs have been recognized as an important contributor of functional ingredients for humans [3]. Egg yolk is composed of various biologically active proteins. The water-soluble proteins of egg yolk have been examined for their functional effects on longitudinal bone growth during the growth period in

• High throughput screening HTS of the AstraZeneca compound co

  2019-11-13

  

  High throughput screening (HTS) of the AstraZeneca Betamethasone Dipropionate collection was conducted and identified oxadiazole amide () originating from a kinase directed screening library (although inactive against a panel of kinases). This compound had moderate potency as a DGAT-1 inhibitor (I

• Sterol regulatory element binding proteins SREBPs

  2019-11-12

  

  Sterol regulatory element binding proteins (SREBPs) regulate transcription of genes involved in fatty PD-1/PD-L1 Inhibitor 3 synthesis [38] (fatty acid synthase, and acetyl-CoA carboxylase) as well as triglyceride synthesis [39]. SREBP-1 protein levels are reduced in 3T3-F442A adipocytes [40] and i

• Recently we have created CRISPR

  2019-11-12

  

  Recently, we have created CRISPR/Cas9-mediated col14a1a knockout fish to interrogate the function of col14a1a during regeneration using the caudal fin model. Using AFM, we showed that collagen XIV-A transiently acts as a molecular spacer responsible for BM biomechanics possibly by helping laminins i

• In a recent report Yoshihara and colleagues used transcripto

  2019-11-12

  

  In a recent report, Yoshihara and colleagues (2016) used transcriptomes derived from freshly isolated islets of 2-week-old neonatal, 6-week-old young adult, or 12-week-old adult mice to interrogate how maturation is regulated to acquire glucose responsiveness. The authors observed that estrogen-rel

• In this work we fabricated a

  2019-11-12

  

  In this work, we fabricated a kind of multifunctional nanoparticles, based on HAuNS coated by chitosan-stearic valdecoxib sale copolymer (CSO-SA), which was employed frequently to form micelles for hydrophobic drug delivery in our previous work [21], [22]. The nanoparticles can encapsulate DiR effi

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