In addition to providing substantial insight

2019-07-17

In addition to providing substantial insight into substrate recognition, structural studies have revealed important details about mechanisms of glycosylation and HCF-1 cleavage [28,30,33]. Activation of the nucleotide-sugar is accomplished through interactions of the β-phosphate with the N-terminus of an α-helix as well as side chain contacts, including a contact with K842, an essential catalytic residue (Figure 2a middle panel).

Calcium dependence of CaM/target

2019-07-16

Calcium dependence of CaM/target interaction was analyzed using a titration matrix in which both Ca2+ and CaM concentrations were changed.

Introduction Current the 5-year survival

2019-07-15

Introduction Current the 5-year survival rates for lung and pancreatic cancers are 18% and 8%, respectively. These low survival rates are partially because of the late diagnosis of one-half of cases, in which 5-year survival decrease to 4% and 3%, respectively. Currently, FDA has approved more than ten anticancer drugs for the treatment of pancreatic cancer but poor survival rates indicates the urgency of the development of novel anticancer drug candidates.

Acknowledgments This study was

2019-07-13

Acknowledgments This study was supported by grants from the Spanish Ministry of Economy and CompetitivenessPI10/00387, PI12/01087, PI12/01703, IPT-2011-0817-010000, and RIC Red de Investigación Cardiovascular (RIC)RD12/0042/0055. RIC is an initiative of Instituto de Salud Carlos III (ISCIII), Spain.

Hello world!

2018-07-29